THE GENERAL HOSPITAL CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
PATEL, SURAJ J.,MILWID, JOHN M.,YARMUSH, MARTIN L.,KING, KEVIN R.
申请号：
EP11798804
公开号：
EP2585109A4
申请日:
2011.06.22
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor； and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2 aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity.
