A topical wound therapeutic treatment provides a gel preparation of very low toxicity and good antimicrobial properties. The gel can be formulated for both intra-oral and extra-oral use. The preparation uses high concentration Xylitol in combination with other agents including a non-Xylitol, sugarless, antimicrobial sweetener, such as DL-Menthol, oil of Peppermint, Sorbitol and Glycerin to achieve rapid wound healing with comfort. The dried gel forms a water soluble occlusive dressing to promote healing.