The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formulalin which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. ln particular, the compounds have the general formula I-A.a' and I-A.a"in which m, E, R1, R3a, R3b, R2, Ry, Rwand Rw6*have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.本發明係關於新穎羧醯胺化合物及其用於製造藥劑之用途。羧醯胺化合物為鈣蛋白酶(calpain)(鈣依賴性半胱胺酸蛋白酶)之抑制劑。因此，本發明亦係關於該等羧醯胺化合物用於治療與鈣蛋白酶活性升高相關聯之病症的用途。羧醯胺化合物為通式I之化合物：其中R1、R2、R3a、R3b、W、Y及X具有申請專利範圍及實施方式中提及之含義，其互變異構體及其醫藥學上合適之鹽。詳言之，該等化合物具有通式I-A.a'及I-A.a"：其中m、E、R1、R3a、R3b、R2、Ry、Rw及Rw6*具有申請專利範圍中提及之含義，n為0、1或2，其互變異構體及其醫藥學上合適之鹽。
