WALDMAN, SCOTT,SNOOK, ADAM,BAYBUTT, TREVOR,MAGEE, MICHAEL
申请号：
CA3093705
公开号：
CA3093705A1
申请日:
2019.03.16
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Proteins comprising anti-GUCY2C scFvs and nucleic acid molecules that encode anti- GUCY2C scFvs are disclosed. Proteins comprising signal sequence linked to anti- GUCY2C scFvs linked to hinge, transmembrane and signal domain sequences are disclosed. Nucleic acid molecules that encode proteins comprising signal sequence linked to anti-GUCY2C scFvs linked to hinge, transmembrane and signal domain sequences are disclosed. T cells that comprise such proteins and such nucleic acid molecules that are disclosed. Methods of making the T cells and methods of using the T cells to treat or prevent cancer that has cancer cells that express GUCY2C are disclosed.
