1. Pyrazol Quine is described in this report, which is characterized by aril orto replace amino, isocyclopropylene-o c832383318327cyclo, with 1 arilo, o-c833228333, 183278327cyclo, a anthrax in place of molecular skeleton 3； The compounds in this module are quina protein activity and therefore contribute to the treatment of diseases caused by uncoupling quina protein activity, especially Mps1 / TTK. This document also provides methods for processing these compounds, including their pharmaceutical components,And a method for treating diseases using drug synthesis including these compounds 1. Claim 1: a compound with formula characteristics (1),e. R1 is an orthogonal arilo group - alternative or heterocyclic bicycles or c83238331832783278cycloquilo group； R2 is a hydrogen atom or c8332121 group, c8331838326alquenilo, c832833183318383832326 tar, c83323238331833183832326 cycloquinolo； or isomeric hetero electrolysis or isooxygenate group； or isomeric isoelectrolytic atom； hydrogen, a. Hydroxyl group or c83216c831832626 tar group, and its component can be recycled with one atom which may represent R3 in the group；a. In this cycle, the orthogonal substitution, arilo and isoprene groups are c8332409 and r8310cm, respectively； e. In addition, c832, 832, 383, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283, 283；There are also acceptable effectsLa presente se refiere a pirazolo-quinazolinas, caracterizadas por un residuo aril-orto-sustituido-amino, heterociclilamino- o C₃₋₇ cicloalquilamino en la posición 8, y un arilo, heterociclilo o C₃₋₇ cicloalquilo como sustituyente de una carboxamida en la posición 3 del esqueleto de la molécula. Los compuestos de esta modulan la actividad de las proteína quinasas, y por lo tanto son útiles para tratar enfermedades causadas por una actividad de proteína quinasa desregulada, en particular MPS1 / TTK. La presente también pro
