Angeline Ingrid Bartholomeusz,Stephen Alister Locarnini,Anna Ayres,Peter William Angus,William Sievert
申请号：
US12833764
公开号：
US08211633B2
申请日:
2010.07.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
