Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.本發明揭示結合VEGF、PDGF及/或其受體中之一或多者之結合蛋白,包括抗體、CDR移植抗體、人類化抗體、結合片段、融合蛋白及其雙特異性或多特異性蛋白質。本發明亦揭示製造及使用該等結合蛋白之方法。