LNA GAPMER OLIGONUCLEOTIDES COMPRISING CHIRAL PHOSPHOROTHIOATE LINKAGES

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专利权人:

发明人:

申请号：

EP15797651.5

公开号：

EP3221329A1

申请日:

2015.11.18

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present relates to LNA gapmer antisense oligonucleotides which comprise stereodefined phosphoramidite linkages. The use of stereodefined phosphoramidite linkages in LNA gapmers has been found to provide enhanced RNaseH activity, and modifying stereospecificity enables the reduced toxicity, altered biodistribution, and enhanced mismatch discrimination.

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