The instant application relates to deazapurines, thienopyrimidines andfuropyrimidines with zinc-binding moietybased derivatives and their use in the treatment of phosphoinositide 3-kinaserelated diseases and disorders such as cancer. Theinstant application further relates to the the treatment of histonedeacetylase related disorders and diseases related to both histonedeacetylase and phosphoinositide 3-kinase.