The invention provides filtered probiotic bacteria lysates derived from Lactobacillus rhamnosus ATCC 53103, or Lactobacillus reuteri ATCC 55730, for manufacture of a medicament and for use in methods of medical and cosmetic treatment, and topical compositions comprising the filtered probiotic lysates. Use in the treatment of infections, including skin infections and methods involving regeneration or repair of the skin barrier are contemplated.
