The invention relates to a pharmaceutical compound of formula (I) or a pharmaceutically acceptable salt or composition thereof, and a method for their use in the treatment of pain, respiratory disease, and inhibition of transient receptor potential A1 ion channel (TRPA1).本發明涉及式(I)的藥物化合物或其藥學上可接受的鹽或組合物,和它們用於治療疼痛、呼吸病症、以及抑制瞬時型感受器電位A1離子通道(TRPA1)的方法。