FORMULATIONS DE LIPIDES ET DE NANOPARTICULES DE LIPIDES POUR L'ADMINISTRATION D'ACIDES NUCLEIQUES

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专利权人:

ACUITAS THERAPEUTICS INC.

发明人:

DU, XINYAO,ANSELL, STEVEN M.

申请号：

CA2990202

公开号：

CA2990202A1

申请日:

2016.06.29

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

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