MCCGEE LAWRENCE R.,HOUZE JONATHAN B.,RUBENSTEIN STEVEN M.,HAGIWARA ATSUSHI,FURUKAWA NOBORU,SHINKAI HISASHI,SH
申请号：
PL35999601
公开号：
PL214670B1
申请日:
2001.06.27
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
Compounds having the formula (I) wherein Ar<；1>； is substituted or unsubstituted 2-benzothiazolyl or substituted or unsubstituted quinolinyl； X is -O-, -C(O)-, -CH(R<；10>；)-, -N(R<；11>；)-, or -S(O)k-； Y is -N(R<；12>；)-S(O)2-； R<；1>； is hydrogen or a specified substituent； R<；2>； is substituted or unsubstituted aryl； and R<；3>； is halogen or (C1-C8)alkoxy are useful in the treatment or prevention of a condition or disorder mediated by PPAR gamma . In particular, the compounds of the invention modulate the function of PPAR gamma . The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
