Genmin Lu,David R. Phillips,Patrick Andre,Uma Sinha
申请号：
US14337074
公开号：
US09388401B2
申请日:
2014.07.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidoes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
