LEE, Jae Won,이제원,PARK, Cheol Won,박철원,JUN, Hun,LEE, Tae Won,이태원,KIM, Nam Hyuck,김남혁,LEE, Sun Young,이선영,YU, Ji Hyuck,유지혁
申请号：
KRKR2014/012677
公开号：
WO2015/102282A1
申请日:
2014.12.23
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical complex formulation comprising an angiotensin II receptor blocker and an HMG-CoA reductase inhibitor and, more specifically, to a granulation process including angiotensin II receptor blocker or a pharmaceutically acceptable salt thereof, a basifying agent and a pharmaceutically acceptable additive, and a pharmaceutical complex formulation prepared by later mixing HMG-CoA reductase inhibitor.La présente invention concerne une formulation complexe pharmaceutique comprenant un inhibiteur de récepteur dangiotensine II et un inhibiteur de réductase HMG-CoA et, plus précisément, un procédé de granulation comprenant un inhibiteur de récepteur dangiotensine II ou un sel pharmaceutiquement acceptable de ce dernier, un agent de base et un additif pharmaceutiquement acceptable, et une formulation complexe pharmaceutique préparée en mélangeant ultérieurement un inhibiteur de réductase HMG-CoA.본 발명은 안지오텐신-Ⅱ 수용체 차단제(AngiotensinⅡ receptor blocker) 및 HMG-CoA 환원효소 저해제를 포함하는 약제학적 복합제제에 관한 것으로, 보다 상세하세는 안지오텐신-Ⅱ 수용체 차단제 또는 이의 약학적으로 허용가능한 염, 염기화제 및 약학적으로 허용가능한 첨가제를 포함하는 과립화하는 공정과, HMG-CoA 환원효소 저해제를 이후에 혼합하여 제조한 약제학적 복합제제에 관한 것이다.
