來自十二指腸布隆納氏腺之幹細胞/前驅細胞及其分離和使用方法农业专利-农业学术服务平台

专利权人:: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;SAPIENZA UNIVERSITA DI ROMA

发明人:: CARPINO, GUIDO,卡皮诺　古多,卡皮諾　古多,CARDINALE, VINCENZO,卡迪奈　文森奏,REID, LOLA M.,瑞德　罗拉Ｍ,瑞德　羅拉Ｍ,ALVARO, DOMENICO,艾法罗　多米尼可,艾法羅　多米尼可,GAUDIO, EUGENIO,古迪欧　尤吉诺,古迪歐　尤吉諾

摘要：: Disclosed herein is Brunner’s Gland Stem/Progenitor Cells (BGSCs) having phenotypic traits of endodermal stem cells and positive for pluripotency markers, and methods of isolating them from the human duodenum. Moreover, the present disclosure provides that BGSCs are easily isolated from duodenum from human donors, can be expanded in culture or induced to differentiate towards hepatic and pancreatic lineages and could represent a cell source for clinical programs of regenerative medicine.本文揭示具有內胚層幹細胞的表型性狀和多能性標記物陽性特性之布隆納氏腺(Brunner’s Gland)的幹細胞/前驅細胞(BGSC)，以及從人類十二指腸中分離出它們的方法。此外，本揭示提供易於從人類提供者的十二指腸中分離出的BGSC，其可在培養液中倍增或誘導分化成肝和胰譜系，並可代表再生醫學臨床程序的細胞來源。