This invention relates to a device (10) for taking at least one sample of soft tissue from an organ, said device comprising a body (11) and a needle (12) formed by a stylet (13) and a cannula (14) coaxial with said stylet, said device comprising a mechanism for arming the needle, designed for sequentially moving the cannula (14) and then the stylet (13) from a rest position wherein the stylet and the cannula are extended towards the outside of the body, to a shooting position wherein the stylet and the cannula are retracted towards the rear of the body, and a triggering mechanism designed to release the stylet then the cannula and to allow their displacement from the shooting position to the rest position, the cannula being coupled kinematically to a cannula slider (24) comprising at least one retaining element (26) for maintaining the cannula slider in a shooting position, the stylet being coupled kinematically to a stylet slider (30) comprising at least one retaining element (32) for maintaining the stylet slider in a shooting position and means for unlocking (34) the cannula slider. The device is characterized in that at least one element among said retaining element of the cannula slider (26) and said retaining element of the stylet slider (32) comprises at least one hook (50, 50′) arranged to cooperate with a retaining device (27, 33) of said hook. The device for taking a sample further includes unlocking means (34, 41) of said arranged hook to release said retaining element from the corresponding retaining device. The sampling device further includes at least one locking element (52, 52′, 52″, 52′″) arranged to prevent said hook to be released from said corresponding retaining device when said locking element is in a locking position and in order to allow said hook to be released from said corresponding retaining device when said locking element is in a position allowing the shot.La présente invention concerne un dispositif (10) pour prélever au moins un échan
