Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof

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专利权人:

Avner Yayon

发明人:

Avner Yayon,Eran Rom

申请号：

US12304638

公开号：

US08101721B2

申请日:

2007.06.17

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other FGF receptors, which block both ligand-dependent and constitutive ligand independent receptor activation. Specifically, the present invention relates to antibodies with high affinity to more than one FGF receptor subtype, and fragments thereof, useful in treating disorders including cell proliferative diseases.

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中国工程科技知识中心

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http://www.ckcest.cn/home/