Ducan Robert R. HISCOCK,Eric Aboagye,Peter IVESON,Quang-De NGUYEN,Susan HOPPMANN,Sebastian TROUSIL,Maciej KALISZCZAK,Giampaolo TOMASI
申请号：
US14900841
公开号：
US20160144062A1
申请日:
2014.06.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is described. The method is for monitoring the response to HSP90 inhibition and comprises the use of the isolated polypeptide conjugated with 18F. The application also describes the use of an isolated polypeptide conjugated with 18F, wherein the isolated polypeptide binds specifically to HER2 or variants thereof, as an imaging agent to monitor uptake thereof to measure HSP90 inhibition.
