FADINI, LUCA,MANINI, PETER,PIETRA, CLAUDIO,GIULIANO, CLAUDIO,LOVATI, EMANUELA,CANNELLA, ROBERTA,VENTURINI, ALESSIO,STELLA, VALENTINO J.
申请号：
PE0006302014
公开号：
PE14212014A1
申请日:
2012.11.28
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds derived from 4 - phenyl substituted pyridines, such as 4 - (5 - (2 - (3,5-bis (trifluoromethyl) phenyl) - n, 2 - dimetilpropanamida) - 4 - (o-tolyl) pyridin-2-yl) - 1 - methyl - 1 - ((fosfonooxi) - What piperazin methyl) - 1 1 - (acetoxymethyl) - 4 - (5 - (2 - (3,5-bis (trifluoromethyl) phenyl) - n, 2 - dimetilpropanamida) - 4 - (or to Lil) pyridin-2-yl) - 1 - 1 - metilpiperazin Io among others.It also relates to a preparation method and a Pharmaceutical composition. These compounds are antagonists of Neurokinin (NK1 receptor) to be useful in the treatment of emesis, bladder Dysfunction, anxietySE REFIERE A COMPUESTOS DERIVADOS DE 4-FENIL-PIRIDINAS SUSTITUIDAS TALES COMO: 4-(5-(2-(3,5-BIS(TRIFLUOROMETIL)FENIL)-N,2-DIMETILPROPANAMIDA)-4-(O-TOLIL)PIRIDIN-2-IL)-1-METIL-1-((FOSFONOOXI)METIL)PIPERAZIN-1-IO 1-(ACETOXIMETIL)-4-(5-(2-(3,5-BIS(TRIFLUOROMETIL)FENIL)-N,2-DIMETILPROPANAMIDA)-4-(O-TOLIL)PIRIDIN-2-IL)-1-METILPIPERAZIN-1-IO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE NEUROQUININA (NK1) SIENDO UTILES EN EL TRATAMIENTO DE EMESIS, DISFUNCION VESICAL, ANSIEDAD
