The invention relates to a medicinal fatheadtree extractive, which is extracted from the plate-typed heartwood, branches, trunks, barks or leaves of rubiaceae nauclea medicinal fatheadtree the obtained medicinal fatheadtree extractive with vincoside-lactam as the principle component can used for preparing the medicines of antisepsis, antivirus, antiphlogosis or anti-hyperthermia. The invention further relates to a medicinal fatheadtree extractive preparation.