PROBLEM TO BE SOLVED: To provide means to obtain virus-like particles with high purity by a simple method.SOLUTION: A method for producing cultures comprising virus-like particles by transforming an insect cell with a baculovirus vector comprising a nucleic acid sequence of a virus and culturing the insect cell is characterized by obtaining cultures after continuing culture until the survival ratio of the insect cell becomes 10% or less.COPYRIGHT: (C)2015,JPO&INPIT