The present invention includes crystalline forms of certain substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.本發明包括某些經取代之含吡啶酮的三環化合物的結晶型,以及包含其之組成物,其可在病患中用於治療或預防患者的B型肝炎病毒(HBV)感染。在某些實施方式中,本發明之化合物及組成物抑制及/或降低HBsAg分泌。