DONG, YIZHOU,LOVE, KEVIN THOMAS,LANGER, ROBERT S.,ANDERSON, DANIEL GRIFFITH,CHEN, DELAI,CHEN, YI,VEGAS, ARTURO JOSE,ALABI, AKINLEYE,ZHANG, YUNLONG
申请号：
AU2012328570
公开号：
AU2012328570A1
申请日:
2012.10.26
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii) or (iii). Such compounds are obtained by reacting the terminal amino group with epoxides or acrylates bearing long chain hydrocarbon groups. The resulting amphiphilic molecules (named "APPLs" in the application) are deemed useful as drug delivery system including nucleotide delivery to cells. Formulae (i), (ii), and (iii) are:
