SYSTEME DE BIOREACTEUR AUTOMATISE, SYSTEME DE MISE EN ƒ；UVRE AUTOMATIQUE D'UN PROTOCOLE POUR LA DECELLULARISATION D'UN ORGANE ET SYSTEME DE DECONTAMINATION DE DECHETS
An automated bioreactor system (100) for decellularizing an organ (5) such as a lung includes a main chamber (15) for containing the organ and at least one reagent chamber (11) containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump (21) drives the flow of the reagent. A perfusion pressure sensor (25) detects a pressure of the flowing reagent. A control system (50) controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system (30) may also be provided.
