Methods of Treatment Using Antisense Oligomers and Conjugates Targeting PCSK9

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专利权人:

ROCHE INNOVATION CENTER COPENHAGEN A/S

发明人:

Nanna ALBÆK,Maj HEDTJÄRN,Marie Wickstrom LINDHOLM,Niels Fisker NIELSEN,Andreas PETRI,Jacob RAVN

申请号：

US15971970

公开号：

US20180312847A1

申请日:

2018.05.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/