ALEXANDER HEGMANS,BRUCE W. FENSKE,DAN J. TREPANIER,MARK D. ABEL,SHIN SUGIYAMA,DAREN R. URE
申请号：
PT11848865
公开号：
PT2651965T
申请日:
2011.12.14
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula (I). The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
