The Johns Hopkins University;Cardioxyl Pharmaceuticals, Inc.
发明人:
John P. Toscano,Frederick Arthur Brookfield,Andrew D. Cohen,Stephen Martin Courtney,Lisa Marie Frost,Vincent Jacob Kalish
申请号：
US14045404
公开号：
USRE045314E1
申请日:
2013.10.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
