LEE, Joon Won,HAN, Won Yong,KIM, Su Jung,OH, Jun Seok,KIM, So Young,HONG, Su Hyeon,SHIN, Yeon Kyeong
申请号：
PE2018003247
公开号：
PE20190448A1
申请日:
2017.06.28
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
You're referring to a stable low viscosity dissolving formula that contains antibodies or fragments of them that bind to antigens (high content, possibly an antibody addition factor? Tumor necrosis (TNF -?) notesInfliximab, adalimuab, etc,A surface active substance (polyurethane, polyxamero, or a mixture of these substances),Sugar (monosaccharide, sugar free or other) or derivatives thereof (sugar alcohol, sugar acid or mixtures thereof),There's also a tampon,It shows excellent stability in long-term storage (based on its excellent stability under accelerated and strict conditions),It can be managed through subcritical. What do you mean, is the method of preparation and use detailed in the formula above, as well as the method of treatment of TNF related diseases? And stabilizes the antibody contained in the formula, and the product, including the formula and the container, is accepted in a closed state. The current invention helps to form a very stable and high level of antibody. Can it be used to treat the clinical problems caused by TNF? (depending on the antibody or fragment used in the formula).Se refiere a una formulacion farmaceutica liquida estable de baja viscosidad que contiene un anticuerpo o su fragmento de union a antigeno (su contenido es elevado, puede ser un anticuerpo que se une al factor ? de necrosis tumoral (TNF-?), infliximab, adalimumab, entre otros), un tensioactivo (polisorbato, poloxamero, o una mezcla de estos), un azucar (monosacarido, disacarido u otros) o su derivado (alcohol de azucar, acido de azucar o una mezcla de estos), y un tampon (acetato o histidina), la cual presenta una excelente estabilidad durante el almacenamiento a largo plazo (esto en base a su excelente estabilidad en condiciones aceleradas y severas), y se puede administrar por via subcutanea. Tambien se refiere a metodos de preparacion y uso de la formulacion detallada lineas arriba, asi como a metodos de tratamiento de una enfermedad relacionada con TNF-? y de estabi
