Present invention is generally directed to the method and compositions with what treatment neurodegenerative disease and disorder, especially ophthalmology disease and disorder. Pharmaceutical composition the present invention provides alkoxy derivative compound and comprising the alkoxy derivative compound. The composition treats and prevents ophthalmology disease and disorder, such as age-related macular degeneration (AMD) and stargardt disease with what.本發明總體而言涉及用於治療神經變性疾病和紊亂,特別是眼科疾病和紊亂的方法和組合物。本發明提供了烷氧基衍生化合物和包含所述烷氧基衍生化合物的藥物組合物。所述組合物用於治療和預防眼科疾病和紊亂,例如年齡相關性黃斑變性(AMD)和斯塔加特氏病。