ROGELIO PEREZ FRUTOS,THOMAS G TAMPONE,JASON ALAN MULDER,DHILEEPKUMAR KRISHNAMURTHY,CHRIS HUGH SENANAYAKE
申请号：
IN7992/DELNP/2010
公开号：
IN2010DN07992A
申请日:
2010.11.12
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
