The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.本發明提供一種雙特異性抗體構築體,其包含結合於標靶細胞表面上之人類CDH19的第一人類結合結構域及結合於T細胞表面上之人類CD3的第二結合結構域。此外,本發明提供一種編碼該抗體構築體之聚核苷酸、包含該聚核苷酸之載體及用該聚核苷酸或載體轉型或轉染之宿主細胞。此外,本發明提供一種用於產生本發明之抗體構築體的方法、該抗體構築體之醫療用途及包含該抗體構築體之套組。
