ROGER NITSCH;JAN GRIMM;UNIVERSITY OF ZURICH;KATHRIN TISSOT;CHRISTOPH HOCK;CHRISTOPH ESSLINGER;MARLEN KNOBLOCH
发明人:
ROGER NITSCH,CHRISTOPH HOCK,CHRISTOPH ESSLINGER,KATHRIN TISSOT,JAN GRIMM,MARLEN KNOBLOCH
申请号：
IL21792312
公开号：
IL217923A
申请日:
2012.02.02
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
