ETUBICS CORPORATION;NANT HOLDINGS IP, LLC;NANTCELL, INC.
发明人:
Frank R. JONES,Adrian RICE,Patrick SOON-SHIONG,Kayvan NIAZI,Shahrooz RABIZADEH
申请号：
US16304740
公开号：
US20200282032A1
申请日:
2017.05.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In certain embodiments, methods and compositions are provided for generating immune responses against tumor neo-antigens or neo-epitopes. In particular embodiments there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor neo-antigens and neo-epitopes that allow for vaccinations in individuals with preexisting immunity to adenovirus. In additional embodiments, methods and compositions are provided for the treatment of cancer using immunotherapy based on recombinant adenovirus-based vectors combined with engineered natural killer cells. In some embodiments, the methods and compositions further comprises a nucleic acid encoding for an immunological fusion partner.
