JIMENEZ, JUAN-MIGUEL,KNEGTEL, RONALD,ROBINSON, DANIEL,COLLIER, PHILIP
申请号：
ES07755181
公开号：
ES2376765T3
申请日:
2007.04.11
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof； wherein R1 is a 3- to 7-membered monocyclic cycloalkyl optionally substituted with 0-4 J1； The Ring is ** Formula ** or R4 is H, C1-6 aliphatic, C3-6 cycloaliphatic, halo (C1-4 aliphatic), 3- to 8-membered heterocyclyl, halo, NO2, CN, OH, OR ", SH , SR ", NH2, NHR", NR "2, COH, COR", CO2H, CO2R ", CONH2, CONHR", CONR "2, OC (O) R", OC (O) NH2, OC (O) N (H) R ", OC (O) NR" 2, N (H) C (O) R ", N (R") C (O) R ", N (H) CO2R", N (R ") CO2R ", N (H) CO2H, N (R") CO2H, N (H) CONH2, N (H) C (O) N (H) R ", N (H) CONR" 2, SO2NH2, SO2N (H) R ", SO2NR" 2, N (H) SO2R ", N (R") SO2R ", P (O) R ', PO2R', P (O) R'2 or P (O) (OR ') 2； R "is unsubstituted C1-6 aliphatic or C1-4 haloaliphatic； or two R groups ", together with the atom to which they are attached, form an unsubstituted 3-8-membered monocyclic ring having 0-1 heteroatoms independently selected from O, N and S； T1 is a C1- aliphatic chain 6 in which 0-3 methylene units of the chain are optionally replaced with -N (R) -, -O-, -S-, -C (O) -, -C (= NR) -, -C ( = NOR) -, -SO- or -SO2-； each T1 20 is optionally substituted with 0-2 JT； R5 is a 5-10-membered aromatic ring containing 0-4 heteroatoms selected from O, N and S； each R5 is optionally substituted with 0-5 J5； J5 is H, C1-6 aliphatic, C3-8 cycloaliphatic, halo (C1-4 aliphatic), 3- to 8-membered heterocyclyl, halo, NO2, CN, OH, 25 OR ' , SH, SR ', NH2, N (H) R', NR'2, C (O) H, C (O) R ', CO2H, CO2R', C (O) NH2, C (O) N (H ) R ', C (O) NR'2, OC (O) R', OC (O) NH2, 'OC (O) NHR', OC (O) N (R ') 2, N (H) C ( O) R ', N (R') C (O) R ', N (H) CO2R', N (R ') CO2R', N (H) CO2H, N (R ') CO2H, N (H) CONH2 , N (H) C (O) NHR ', N (H) CON (R') 2, SO2NH2, SO2NHR ', SO2NR'2, N (H) SO2R ', N (R') SO2R ', P (O) R', PPO2R ', P (O) R'2 or P (O) OR'2； R is H or C1-6 aliphatic unsubstituted； R 'is unsubstituted C1-6 aliphatic or C1-4 haloaliphatic； or two R 'groups, together with the atom to which they are
