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CO-PRÉCIPITATION DE TOBRAMYCINE DANS DES REVÊTEMENTS D'HYDROXYAPATITE
专利权人:
Stryker European Holdings I; LLC
发明人:
申请号:
EP14742357.8
公开号:
EP3010557B1
申请日:
2014.06.19
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
A method for co-precipitating a therapeutic agent into a hydroxyapatite coated surface includes the steps of providing a surface and applying a hydroxyapatite seed layer on the surface. The hydroxyapatite seed layered surface is contacted with a solution including the therapeutic agent and a co-precipitated therapeutic agent, hydroxyapatite layer is formed on the coated surface to uniformly distribute the therapeutic agent in the layer. Further, an implant having sustained therapeutic agent delivery includes a base and an hydroxyapatite seed layer disposed on a surface of the base. A co-precipitated hydroxyapatite coating is disposed on the seed layer. The coating includes a therapeutic agent, wherein the therapeutic agent is provided in a solution of therapeutic agent.
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