KELER, TIBOR,GRAZIANO, ROBERT,TREML, JOHN,DEO, YASHWANT M.
申请号：
CA2471702
公开号：
CA2471702C
申请日:
2003.01.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Isolated human monoclonal antibodies which bind to CD30 (e.g., human CD30) aredisclosed. The human antibodies can be produced in a non-human transgenicanimal, e.g., a transgenic mouse, capable of producing multiple isotypes ofhuman monoclonal antibodies by undergoing V-D-J recombination and isotypeswitching. Also disclosed are derivatives of the human antibodies (e.g.,bispecific antibodies and immunoconjugates), pharmaceutical compositionscomprising the human antibodies, non-human transgenic animals and hybridomaswhich produce the human antibodies, and therapeutic and diagnostic methods forusing the human antibodies.
