NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
发明人:
Heiichiro UDONO,Shingo EIKAWA,Shin-ichi TOYOOKA
申请号：
US15503247
公开号：
US20170231929A1
申请日:
2015.08.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides a method for enhancing immune cell function by activating various immune cells ex vivo and provides immune cells with enhanced function. The invention further provides an immune-related cell multifunctionality evaluation method. A biguanide antidiabetic drug selected from metformin, phenformin, and buformin is capable of enhancing immune cell multifunctionality by increasing CD8+T cells having a high ability to produce IL-2, INFα, and IFNγ. The immune-related cell multifunctionality may be evaluated by comparing immune cells treated with a biguanide antidiabetic drug selected from metformin, phenformin, and buformin, with control immune cells untreated with the biguanide antidiabetic drug. When the multifunctionality of immune cells treated with the biguanide antidiabetic drug selected from metformin, phenformin, and buformin is determined to be significantly increased compared with the control, it can be evaluated that the sensitivity of the immune cells to the therapeutic agent is improved.
