The disclosure generally provides antibodies and antigen binding fragments of antibodies that bind ticagrelor and metabolites of ticagrclor. The disclosure also provides compositions comprising the antibodies, nucleic acid molecules encoding the antibodies, methods of treating a patient comprising administering the antibodies, and methods of making and using the antibodies.本發明大體上提供結合替格瑞洛(ticagrelor)及替格瑞洛代謝物的抗體及抗體之抗原結合片段。本發明亦提供包括該等抗體之組合物、編碼該等抗體之核酸分子、治療患者之方法(其包括投與該等抗體)、及製備與使用該等抗體之方法。
