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METHODS OF INHIBITING FUNGAL CERAMIDE SYNTHASE FOR TREATMENT OF CRYPTOCOCCUS NEOFORMANS INFECTION
专利权人:
The Research Foundation for the State University of New York
发明人:
Maurizio Del Poeta,Mansa Munshi,Krupanandan Haranahalli,Karen You,Iwao Ojima
申请号:
US16495605
公开号:
US20200171132A1
申请日:
2018.03.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides a method of inhibiting the growth of a fungus comprising contacting the fungus with an effective amount of an inhibitor so as to thereby inhibit the growth of the fungus, wherein the inhibitor inhibits ceramide synthase 1 (Cer1) in the fungal cells of the fungus. The present invention also provides method of treating a subject afflicted with a fungal infection comprising administering to the subject an effective amount of an inhibitor so as to treat the subject afflicted with the fungal infection, wherein the inhibitor inhibits ceramide synthase 1 (Cer1) in the fungal cells of the fungus.
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