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TRPV4 ANTAGONIST
- 专利权人:
- GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
- 发明人:
- CARL A BROOKS,GUOSEN YE,PATRICK STOY
- 申请号：
- BR112018073700
- 公开号：
- BR112018073700A2
- 申请日:
- 2017.05.18
- 申请国别(地区):
- BR
- 年份:
- 2019
- 代理人:
- 摘要：
- It is a novel compound useful as a trpv4 antagonist, specifically 1 - (((5 s, 7r) -3- (5-cyclopropylpyrazin-2-yl) -7-hydroxy-2-oxo-1). -oxa-3-azaspiro [4,5] decan-7-yl) methyl) -1h-benzo [d] imidazol-6-carbonitrile, pharmaceutically acceptable salts and pharmaceutical compositions containing the compound. The compound of the invention may be useful in treating a disease state selected from: atherosclerosis, disorders related to vasogenic edema, postoperative abdominal edema, eye edema, cerebral edema, local and systemic edema, fluid retention, sepsis, hypertension, inflammation, bone-related dysfunction and congestive heart failure, lung disorders, chronic obstructive pulmonary disorder, ventilator-induced lung injury, high altitude induced pulmonary edema, acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, sinusitis / rhinitis, asthma, cough； including being acute,subacute cough and chronic cough, pulmonary hypertension, hyperactive bladder, cystitis, pain, motor neuron disorders, genetic gain of function disorders, cardiovascular disease, renal dysfunction, stroke, glaucoma, retinopathy, endometriosis, premature labor, dermatitis, rash, itching in liver disease, diabetes, metabolic disorder, obesity, migraine, pancreatitis, tumor suppression, immunosuppression, osteoarthritis, Crohn's disease, colitis, diarrhea, intestinal irregularity (hyperreactivity / hyperreactivity), fecal incontinence, irritable bowel syndrome (sii), constipation, intestinal pain and cramps, celiac disease, lactose intolerance and flatulence.trata-se de um novo composto útil como um antagonista de trpv4, especificamente o composto 1-(((5 s,7 r)-3-(5-ciclopropilpirazin-2-il)-7-hidróxi-2-oxo-1-oxa-3-azaspiro[4,5]decan-7-il)metil)-1h-benzo[d]imidazol-6-carbonitrila, sais farmaceuticamente aceitáveis e composições farmacêuticas con-tendo o composto. o composto
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
