The present invention relates to a process for producing preparation of natural medicines (i.e., Chinese traditional herbs). Particularly, the present invention relates to a process for bio-conversion or bio-modification of any plant or animal original natural medicines by the intestinal probiotics fermentation culture which mimic the micro-ecosystem in human intestinal tract in the light of the bionics theory and whereby the biological activity of said natural medicines is improved and toxic thereof is reduced or eliminated. The present invention further relates to the use of said process in producing of natural Chinese herbal preparation.
