The invention features methods for treatment of a patient in need thereof with the administration of mammalian target of rapamycin (mTOR) inhibitors such as sirolimus, temsirolimus, everolimus or rapamycin analogs including AP23573, especially to a cancer patient for 4 or 5 consecutive days per week. The mTOR inhibitor therapy can be used for a wide range of cancers including prostrate, pancreas, ovary, lung, breast, bladder, colon, brain, head and neck, endometrium, leukemia, lymphoma and sarcoma.
