Mary Elizabeth Pecquet Goad,Denis Schrier,Allen Richard Pierce
申请号：
US14215232
公开号：
US20140342976A1
申请日:
2014.03.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily. According to the invention, an exemplary bioactive agent is BMP-7 The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the site of intravascular delivery of the bioactive agent.
