МЭЙНС Тимоти Дж. (US),МАЧИЛС Бернандус Н М (US),МЕХТА Бхарат М. (US),УАЙСЛЕР Джеральд (US),ДЭВИДСОН Майкл (US),ВУД Питер Ральф (GB)
申请号：
RU2018116572
公开号：
RU2018116572A
申请日:
2013.01.04
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
The invention discloses one pharmaceutical compositions of use for including: eicosapentaenoic acid (" EPA "), in 50% to 60% weight percent amount Docosahexaenoic acid (" DHA ") in 17% to 23% weight percent amount Docosapentaenoic acid (n-3) (" DPA ") in 1% to 8% weight percent amount It wherein by polyunsaturated acid weight in the composition at least 90% is present in free acid form, in the manufacture of a medicament for treating violent hypertriglyceridemia, wherein treatment includes: to manage by word of mouth to a patient, it is with Pretreatment serum or plasma triglyceride level >=500 milligrams/dL, and in quantity and an effective duration reduces slurries or plasma triglyceride below pretreatment level. Also disclose including use one pharmaceutical composition: EPA, substantially in free acid form, with 55.1% (m/m) to 58.The amount of 4% (m/m) DHA, substantially in free acid form, with 17.7% (m/m) to 22.The amount of 2% (m/m) DPA, substantially in free acid form, with 2.1% (m/m) to 8.The amount of 5% (m/m) In the manufacture of the medicament for the treatment with raised pretreatment blood or a patient of plasma triglyceride, wherein treatment includes: that management medicament reduces arachidonic acid (AA) RP-HPLC at least about 5% 1 duration in quantity and to be effective. It is further disclosed that a kind of method for manufacturing a pharmaceutical composition of the polyunsaturated fatty acid in free acid form, including method :(a) make include the transesterify fish oil of the ethyl ester of EPA one among raw material, with at least about 44% amount (one/a), DHA, with at least about 14% amount (one/a), and DPA, at least about 1% amount (one/a), to a step of urea inclusion complexing (b) resulting urea complex is removed (c) non-combined PUFA esters are hydrolyzed to free fatty acid The amount of urea for complexing is wherein calculated according to formula I (a), or according to formula I (b), or according to formula I (a) and formula I (b
