FOX, CHRISTOPHER B.,KHANDHAR, AMIT PRAFUL,VAN HOEVEN, NEAL,ERASMUS, JESSE H.,LIN, SUSAN S.
申请号：
CA3067224
公开号：
CA3067224A1
申请日:
2018.06.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.
