Ravi V.J. Chari;Wayne C. Widdison;Sharon D. Wilhelm
发明人:
Ravi V.J. Chari,Wayne C. Widdison,Sharon D. Wilhelm
申请号：
US13883344
公开号：
US20130323268A1
申请日:
2011.11.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
