ABUCHOWSKI, ABRAHAM,JUBIN, RONALD G.,BUONTEMPO, PETER J.,KAZO, FRIEDERICKE
申请号：
CA2988988
公开号：
CA2988988A1
申请日:
2016.06.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This invention relates to novel PEGx-GCSF conjugates, wherein x is the amount of PEG per GCSF and ranges from 4 to 8. The invention also relates to PEG[x]-GCSF populations of individual PEGx-GCSF conjugates, wherein [x] is the average amount of PEG per GCSF of the population and is 4 or greater. The inventive compositions have unexpected therapeutic efficacy, while avoiding or substantially reducing the likelihood of adverse side effects.
