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Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
专利权人:
Franklin Volvovitz
发明人:
Franklin Volvovitz
申请号:
US10943502
公开号:
US08299062B2
申请日:
2004.09.17
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents, organophosphate insecticides and incapacitating agents of the central nervous system (CNS); CNS injury, including traumatic brain injury, neurologic complications of cardiac surgery, perinatal asphyxia, and stroke, spinal cord injury, and peripheral nerve injury; and neuronal disorders associated with the loss of motor function including post-polio syndrome, amyotrophic lateral sclerosis, myasthenia gravis, Parkinson's disease and Rett syndrome; neurodegenerative disorders including Alzheimer's disease, mild cognitive impairment and schizophrenia; and cognitive impairment associated with aging. The compositions of the invention preferably comprise in effective amounts (a) at least one acetylcholinesterase inhibitor, (b) at least one compound with anticholinergic properties or both anticholinergic and antiglutamatergic properties, (c) optionally an anticonvulsive compound, and a pharmaceutically acceptable carrier.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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