PREMIXTURE AND PHARMACEUTICAL COMPOSITION FOR THE ORAL ADMINISTRATION OF MEMANTINE AS A PERMANENT SUSPENSION OR PREPARED PRIOR TO ADMINISTRATION TO THE PATIENT, OPTIONALLY VIA AN ENTERAL FEEDING TUBE, AND CORRESPONDING METHODS
Pharmaceutical composition of memantine for administering orally which comprises a premixture comprising:i) between 74 and 85% w/w total of the premixture of a granulate of pellets comprising memantine between 10 and 15% w/w total of the premixture coated by first coating of polyvinylpyrrolidone, and a second coating comprising between 80 and 95% w/w total of the coating of cationic copolymer of dimethylaminoethyl methacrylate, butyl methacrylate and methyl methacrylate and between 5 and 20% w/w total of the coating of magnesium stearateii) between 4 and 7% w/w total of the premixture of sucraloseiii) between 11 and 19 % w/w total of the premixture of essences.All the components have a particle size smaller than 710 microns. The composition can be a suspension, a powder for preparing a suspension or an oral disintegrating tablet. It can also be used to be administered through a nasogastric tube.
